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Ownership Profile

Shareholder Breakdown
Shareholder Holders Values ($) % O/S Shares
Institution 36 70 62.62 3,939,750
Mutual Fund 8 1 0.67 42,297
Institutional Shareholder Rotation
Shareholder Holders Values Change ($) % O/S Shares Change
Buyers 11 46.36 41.81 2,630,571
Sellers 18 -1.52 2.01 -126,425
Net -- 44.83 39.80 2,504,146
Institutional Shareholder Concentration
Shareholder Values ($) % O/S Shares
Top 10 Inst. 69 61.96 3,898,817
Top 20 Inst. 69.73 62.55 3,935,918
Top 50 Inst. 69.80 62.62 3,939,750
Total Inst. 69.80 62.62 3,939,750
Institutional Shareholder Style
Shareholder Holders Values ($) % O/S Shares
Index 3 1 1.51 42,503
CoreGrowth 2 0 0.07 1,916
Growth 1 0 0.00 49
VCPrivateEquity 3 45 90.90 2,564,304
HedgeFund 3 3 5.85 165,028
SectorSpecific 1 0 1.34 37,786
GARP 1 0 0.13 3,620
BrokerDealer 5 0 0.04 1,247
CoreValue 1 0 0.05 1,396
DeepValue 2 0 0.00 38
Top Holders: Institutional Investor
Holder Shares Held % O/S Shares Change Filing Date
Phase4 Ventures Limited 1,165,447 18.52 1,165,447 12/01/2016
AstraZeneca Plc 1,008,141 16.02 1,008,141 12/01/2016
TPG Capital, L.P. 777,096 12.35 777,096 12/31/2016
TVM Capital GmbH 621,761 9.88 621,761 12/01/2016
Renaissance Technologies LLC 148,838 2.37 17,338 12/31/2016
Chiswell (David Ph.D.) 56,278 0.89 56,278 12/01/2016
Phase4 Partners, Ltd. 38,848 0.62 38,848 11/03/2016
OrbiMed Advisors, LLC 37,786 0.60 37,786 12/31/2015
The Vanguard Group, Inc. 28,465 0.45 -18,005 12/31/2016
Rosalind Advisors, Inc. 16,157 0.26 -94,840 12/31/2015
Geode Capital Management, L.L.C. 13,158 0.21 9,256 12/31/2016
Cooper (Ronald Harold Wilfred) 5,946 0.09 5,946 12/01/2016
De Souza (Errol B) 5,313 0.08 -1 12/01/2016
PanAgora Asset Management Inc. 3,620 0.06 -2 12/31/2016
Psagot Investment House Ltd. 2,367 0.04 0 12/31/2016
Mattsson (Jan Ph.D.) 1,974 0.03 1,974 11/03/2016
Guggenheim Investments 1,396 0.02 0 01/31/2017
Group One Trading, L.P. 1,257 0.02 -421 12/31/2016
Krasner (Alan) 1,190 0.02 0 08/15/2016
BlackRock Institutional Trust Company, N.A. 880 0.01 -4,210 12/31/2016
Bavier (Paul S) 677 0.01 44 12/01/2016
Deutsche Asset Management Americas 659 0.01 659 12/31/2016
Cutler Group, LP 615 0.01 -237 12/31/2016
Deutsche Bank Securities Inc. 587 0.01 587 12/31/2016
Morgan Stanley & Co. LLC 451 0.01 451 12/31/2016
Lieberman (Ira W) 376 0.01 0 08/15/2016
Bank of America Merrill Lynch (US) 200 0.00 157 12/31/2016
Ginsberg (Barry H) 64 0.00 0 08/15/2016
Plante Moran Financial Advisors, LLC 49 0.00 0 12/31/2016
Lorber (Daniel) 43 0.00 0 08/15/2016
Ladenburg Thalmann Asset Management Inc. (LTAM) 33 0.00 0 12/31/2016
North Star Investment Management Corporation 33 0.00 33 12/31/2016
Zorn (Peter A) 31 0.00 31 11/03/2016
Wells Fargo Advisors 8 0.00 0 12/31/2016
Creative Planning, Inc. 5 0.00 0 12/31/2016
UBS Securities LLC 1 0.00 -929 12/31/2016

Ownership data is provided by Thomson Reuters, a third party service, and Albireo does not maintain or provide information directly to this service.

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