Ownership Profile

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
Perceptive Advisors LLC 1,704,330 13.44 -- 6/30/19
Federated Global Investment Management Corp. 1,437,000 11.33 717,405 6/30/19
Satter Muneer A 832,000 6.56 -- 12/31/18
TPG Capital, L.P. 716,381 5.65 -- 6/30/19
TVM Capital GmbH 621,761 4.90 -- 4/1/19
BlackRock Institutional Trust Company, N.A. 596,393 4.70 75,858 6/30/19
ArrowMark Colorado Holdings, LLC 555,728 4.38 -104,714 6/30/19
AstraZeneca PLC 508,141 4.01 -500,000 12/1/17
Invus Public Equities Advisors, LLC 450,000 3.55 -50,000 6/30/19
Fidelity Management & Research Company 420,100 3.31 -- 6/30/19

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 118 333.55 81.99 10,316,825
Mutual Fund 178 103.12 27.27 3,280,352
Insider 9 25.27 7.71 978,085

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 24 19.28 4.80 603,534
Aggressive Growth 2 4.06 0.99 125,842
Core Growth 18 14.52 3.63 455,815
Growth 4 0.71 0.18 21,877
Income 2 1.70 0.43 52,781
Income Value 1 0.89 0.22 27,591
Yield 1 0.81 0.21 25,190
Index 18 40.51 9.92 1,257,709
Other 38 173.03 42.40 5,330,825
Broker Dealer 9 1.80 0.44 55,693
GARP 9 29.83 7.39 925,306
Hedge Fund 16 89.85 21.98 2,787,108
Specialty 1 0.71 0.23 27,571
VC Private Equity 3 50.85 12.36 1,535,147
Value 17 72.34 17.77 2,244,216
Core Value 13 48.92 11.98 1,517,695
Deep Value 4 23.42 5.78 726,521

* Insider values reflect direct beneficial ownership.

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