Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 82 318.88 83.74 10,000,760
Mutual Fund 36 44.87 12.02 1,435,652
Insider 2 1.21 0.32 38,714

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 56 115.88 30.00 3,582,296
Sellers 16 -12.79 3.56 -425,229
Net -- 103.09 26.44 3,157,067

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 318.88 83.74 10,000,760
Top 10 Inst. 235.59 61.96 7,399,595
Top 20 Inst. 285.54 74.87 8,941,217
Top 50 Inst. 316.80 83.20 9,936,055

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 12 6.76 1.73 206,603
Aggressive Growth 1 4.07 1.05 125,000
Core Growth 9 2.64 0.67 80,042
Growth 2 0.05 0.01 1,561
Income 1 0.31 0.08 9,626
Income Value 1 0.31 0.08 9,626
Index 9 8.27 2.13 254,560
Momentum 1 0.33 0.08 10,100
Other 31 206.46 53.21 6,354,116
Broker Dealer 7 3.27 0.84 100,536
GARP 5 30.30 7.86 938,860
Hedge Fund 15 92.29 23.73 2,834,061
Specialty 1 0.53 0.14 16,355
VC/Private Equi 3 80.05 20.64 2,464,304
Value 12 28.59 7.55 901,319
Core Value 8 12.25 3.35 399,758
Deep Value 4 16.34 4.20 501,561

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
Perceptive Advisors LLC 1,704,330 14.27 384,330 3/31/18
Phase4 Ventures Limited 1,065,447 8.92 -100,000 1/30/18
Satter Muneer A 832,000 6.97 -- 4/1/18
TPG Capital, L.P. 777,096 6.51 -- 4/1/18
Fidelity Management & Research Company 627,732 5.26 627,732 3/31/18
TVM Capital GmbH 621,761 5.21 -- 4/1/18
Invus Public Equities Advisors, LLC 547,841 4.59 247,841 3/31/18
AstraZeneca Plc 508,141 4.26 -500,000 12/1/17
ArrowMark Colorado Holdings, LLC 405,352 3.39 405,352 3/31/18
Federated Global Investment Management Corp. 309,895 2.60 309,895 3/31/18

* Insider values reflect direct beneficial ownership.

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