Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 116 308.67 79.10 9,523,508
Mutual Fund 170 101.86 26.55 3,180,234
Insider 9 25.27 8.12 978,085

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 46 19.22 4.97 598,353
Sellers 40 -41.28 12.24 -1,473,636
Net -22.05 7.27 -875,283

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 346.95 91.45 11,009,734
Top 10 Inst. 223.64 59.83 7,203,285
Top 20 Inst. 290.96 77.07 9,278,139
Top 50 Inst. 337.58 89.02 10,717,855

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 25 17.60 4.58 551,207
Aggressive Growth 2 4.77 1.23 148,193
Core Growth 19 12.14 3.17 381,895
Growth 4 0.68 0.18 21,119
Income 2 1.82 0.47 56,601
Income Value 1 0.89 0.23 27,689
Yield 1 0.93 0.24 28,912
Index 16 35.61 9.18 1,105,781
Other 36 173.09 44.15 5,315,820
Broker Dealer 9 1.24 0.32 38,495
GARP 8 30.28 7.68 925,167
Hedge Fund 15 89.64 23.12 2,783,222
Specialty 1 1.11 0.28 33,789
VC Private Equity 3 50.82 12.75 1,535,147
Value 22 53.04 13.67 1,646,185
Core Value 16 25.75 6.64 798,981
Deep Value 6 27.29 7.04 847,204

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
Perceptive Advisors LLC 1,704,330 14.16 -- 3/31/19
Satter Muneer A 832,000 6.91 -- 12/31/18
Federated Global Investment Management Corp. 719,595 5.98 133,449 3/31/19
TPG Capital, L.P. 716,381 5.95 -- 3/31/19
ArrowMark Colorado Holdings, LLC 660,442 5.49 48,450 3/31/19
TVM Capital GmbH 621,761 5.16 -- 4/1/19
BlackRock Institutional Trust Company, N.A. 520,535 4.32 -12,283 3/31/19
AstraZeneca PLC 508,141 4.22 -- 12/1/17
Invus Public Equities Advisors, LLC 500,000 4.15 -- 3/31/19
Fidelity Management & Research Company 420,100 3.49 -60,900 3/31/19

* Insider values reflect direct beneficial ownership.

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