Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 119 344.01 97.94 11,723,387
Mutual Fund 146 81.70 24.97 2,989,072
Insider 5 1.67 0.46 55,448

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 49 19.89 5.88 703,458
Sellers 41 -11.00 2.88 -345,076
Net -- 8.89 3.00 358,382

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 344.01 97.94 11,723,387
Top 10 Inst. 232.57 63.69 7,623,091
Top 20 Inst. 291.68 82.35 9,857,378
Top 50 Inst. 337.14 95.79 11,466,463

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 22 13.11 4.17 499,432
Aggressive Growth 1 3.07 1.04 125,000
Core Growth 17 9.53 2.96 353,725
Growth 4 0.52 0.17 20,707
Income 2 1.35 0.46 55,065
Income Value 1 0.67 0.23 27,406
Yield 1 0.68 0.23 27,659
Index 17 28.30 9.13 1,092,509
Momentum 1 0.30 0.10 12,100
Other 35 197.05 52.98 6,341,124
Broker Dealer 9 0.69 0.18 21,682
GARP 7 24.75 8.32 995,634
Hedge Fund 14 85.78 22.40 2,681,029
Specialty 1 1.10 0.35 42,185
VC/Private Equi 4 84.74 21.73 2,600,594
Value 20 38.10 11.33 1,356,132
Core Value 13 15.75 5.31 636,024
Deep Value 7 22.35 6.02 720,108

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
Perceptive Advisors LLC 1,704,330 14.24 -- 9/30/18
Phase4 Ventures Limited 1,065,447 8.90 -100,000 1/30/18
Satter Muneer A 832,000 6.95 -- 4/1/18
TPG Capital, L.P. 716,381 5.98 -- 9/30/18
TVM Capital GmbH 621,761 5.19 -- 4/1/18
Federated Global Investment Management Corp. 586,146 4.90 -- 12/31/18
ArrowMark Colorado Holdings, LLC 556,067 4.65 42,818 9/30/18
BlackRock Institutional Trust Company, N.A. 532,818 4.45 -2,538 12/31/18
AstraZeneca Plc 508,141 4.25 -500,000 12/1/17
Invus Public Equities Advisors, LLC 500,000 4.18 -- 12/31/18

* Insider values reflect direct beneficial ownership.

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