Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 115 267.00 88.11 10,596,035
Mutual Fund 147 79.35 24.29 2,920,547
Insider 5 1.84 0.47 56,474

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 35 15.24 5.16 620,121
Sellers 42 -40.55 12.35 -1,485,613
Net -- -25.31 7.19 -865,492

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 267.00 88.11 10,596,035
Top 10 Inst. 178.33 58.99 7,094,569
Top 20 Inst. 228.33 75.64 9,096,088
Top 50 Inst. 260.93 86.13 10,357,884

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 24 12.39 4.19 504,040
Aggressive Growth 2 3.66 1.24 149,216
Core Growth 18 8.21 2.78 334,117
Growth 4 0.52 0.17 20,707
Income 2 1.35 0.46 55,065
Income Value 1 0.67 0.23 27,406
Yield 1 0.68 0.23 27,659
Index 15 26.83 9.09 1,093,510
Momentum 1 0.30 0.10 12,100
Other 34 132.80 43.34 5,211,569
Broker Dealer 9 1.26 0.43 51,486
GARP 7 25.47 8.33 1,001,548
Hedge Fund 14 63.39 21.49 2,584,144
Specialty 1 1.26 0.33 39,244
VC/Private Equi 3 41.41 12.77 1,535,147
Value 17 34.73 11.72 1,409,337
Core Value 11 15.69 5.27 633,309
Deep Value 6 19.04 6.45 776,028

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
Perceptive Advisors LLC 1,704,330 14.17 -- 12/31/18
Satter Muneer A 832,000 6.92 -- 12/31/18
TPG Capital, L.P. 716,381 5.96 -- 12/31/18
TVM Capital GmbH 621,761 5.17 -- 4/1/18
ArrowMark Colorado Holdings, LLC 611,992 5.09 55,925 12/31/18
Federated Global Investment Management Corp. 586,146 4.87 -- 12/31/18
BlackRock Institutional Trust Company, N.A. 532,818 4.43 -2,538 12/31/18
AstraZeneca Plc 508,141 4.23 -500,000 12/1/17
Invus Public Equities Advisors, LLC 500,000 4.16 -- 12/31/18
Fidelity Management & Research Company 481,000 4.00 -- 12/31/18

* Insider values reflect direct beneficial ownership.

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